I have been having a great time hunting giants and mammoths with my level 47 Alik'r.
Started by climbing up on unreachable clifts and rocks and using archery and flame atronarchs to kill them. Now I sometimes use frenzy to reduce their numbers followed by long range archery and then chopping to bits with my scimiter. Alternatively, I use archery followed by running and sneaking to avoid melee.
How do you hunt them?