December 2, 2011 2:26 PM EST
Without spoiling anything,
If you follow any of the major quests you will run into so many Unique two handed items that you won't be able to carry them all.
At this point, I just make my own.
My fav is a 2 handed ebony warhammer that does 72 damage, gives me 30 health every time it hits, and I have maxed our my two-handed tree to include decapitations.